News

News

Press Releases | Presentations | Publications | In the News

Press Releases

Press releases

February 13, 2025
Ensoma Receives Rare Pediatric Disease and Orphan Drug Designations for EN-374 for Treatment of Chronic Granulomatous Disease
November 5, 2024
Ensoma Unveils Three Programs Leveraging In Vivo Hematopoietic Stem Cell Engineering Platform to Target Genetic, Immune and Oncological Diseases
October 28, 2024
Ensoma Appoints Accomplished Deal Maker Jon Garen as Chief Corporate Development and Business Officer
May 13, 2024
Ensoma Appoints Accomplished Company Builder and Product Developer, Jim Burns, Ph.D., as Chief Executive Officer
May 16, 2023
Ensoma Closes Series B Extension, Bringing Total Round to $135 Million
February 9, 2023
Ensoma Announces Closing of Twelve Bio Acquisition
Presentations

Presentations

ASH 2024 | December 9, 2024
Single Dose of tGroβ (EN-145)/Plerixafor Safely and Effectively Mobilizes Primitive HSCs in Mouse Models for In Vivo Gene Therapy of Sickle Cell Disease
ASH 2024 | December 7, 2024
In Vivo Hematopoietic Stem Cell Engineering Restores the Function of NADPH Enzyme Complex in X-Linked Chronic Granulomatous Disease Model Mice
SITC 2024 | November 7, 2024
In vivo VLP-based engineering generates multi-lineage CAR-immune cells that mediate potent and durable anti-tumor activity
Chardan 8th Annual Genetic Medicines Conference | October 1, 2024
Curative medicines through precision in vivo cellular engineering
Publications

Publications

Blood | April 27, 2023
In vivo HSC prime editing rescues sickle cell disease in a mouse model
JCI Insight | August 25, 2022
In vivo base editing by a single intravenous vector injection for treatment of hemoglobinopathies
Blood Advances | July 29, 2022
In vivo HSC transduction in rhesus macaques with an HDAd5/3+ vector targeting desmoglein 2 and transiently overexpressing cxcr4
Blood Advances | February 23, 2021
In vivo HSPC gene therapy with base editors allows for efficient reactivation of fetal γ-globin in β-YAC mice
Molecular Therapy | September 5, 2020
In vivo HSC gene therapy using a bi-modular HDAd5/35++ vector cures sickle cell disease in a mouse model
JCI Insight | August 20, 2020
Curative in vivo hematopoietic stem cell gene therapy of murine thalassemia using large regulatory elements
In the News

In the news

Biopharma Dealmakers | March 1, 2024
Precision CRISPR for in vivo genome engineering
Evaluate Vantage | May 9, 2023
Gene editing: overhyped or unstoppable tide?
BioPharma Dive | January 6, 2023
Ensoma buys a startup to advance ‘in vivo’ cell therapy work
BioCentury | January 6, 2023
In vivo cell therapy technology advances with Ensoma’s Twelve Bio acquisition
Nature Biotechnology | November 3, 2022
Nature Biotechnology’s academic spinouts 2021
BioPharma Dive | October 18, 2022
‘In vivo’ cell therapy: expanding beyond CAR-T

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